Excellent cushioned stability shoe for runners who want plush comfort and gentle support.
You know that feeling when your feet ache five miles into a run or when you need a shoe that soaks up long miles without nagging pain? The Brooks Men's Glycerin GTS 21 aims to solve exactly that. It pairs thick, soft cushioning with mild support to keep your stride smooth and your legs less tired. If you log steady miles, deal with mild overpronation, or simply want a sofa-like feel underfoot for daily runs, this shoe is built for that comfort-first mission.
Is Brooks Men’s Glycerin GTS 21 Good?
Yes — the Brooks Men’s Glycerin GTS 21 is a strong pick for runners who want max cushioning with light stability. In short: it’s best for daily miles, recovery runs, and anyone who values plush comfort without giving up basic support for mild overpronation. For me, the Glycerin GTS 21 became the go-to shoe for long easy days. I used it for back-to-back moderate runs and noticed less lower-leg fatigue than with my firmer trainers. On a separate weekend, I swapped it in for a recovery run after a race, and my calves felt noticeably less sore.
This shoe won’t be the fastest for tempo work. But if you want a smooth, protected ride that helps you log miles pain-free, the Brooks Men’s Glycerin GTS 21 earns a solid yes. It blends plush DNA LOFT cushioning with GuideRails support to keep things comfy and steady.
My First Impression for Brooks Men’s Glycerin GTS 21
The shoes arrived in a standard box with clear sizing labels. The pair looked clean and well-assembled out of the box. The knit upper felt soft and slightly plush. I noted solid stitch work and a beefy midsole right away. Lacing was straightforward and the collar padding felt generous.
My first walk around the block was revealing. The shoe felt like stepping onto a soft pillow. The midsole had that pillowy DNA LOFT feel, and the GuideRails side panels gave a subtle sense of containment. On first short runs, the ride felt smooth and forgiving. I was excited but not surprised — Brooks has a track record of delivering comfort-first daily trainers. Overall, first impressions leaned positive: quality build, cozy fit, and a clearly cushioned ride.
What Makes It Stand Out / Key Features
- Plush DNA LOFT v3 midsole foam for maximum cushioning and impact absorption
- GuideRails support system to reduce excess movement and guide your gait
- Soft engineered knit upper for comfort and a secure fit
- Improved outsole pattern for confident traction and even wear
- Available in wider widths for a roomier toe box and better fit options
- Durable construction built for high-mileage daily use
What I Like
- Exceptional cushioning that reduces impact on long runs
- Gentle stability that helps mild overpronators without feeling rigid
- Comfortable upper that minimizes hot spots and blisters
- Good durability for a daily trainer—midsole holds up over many miles
- Available wide-fit option, great for runners with broader feet
- Smooth, confidence-inspiring ride for easy and recovery runs
What Could Be Better
- Heavier than more responsive trainers—less suited to speed work
- Higher price point compared to some neutral daily shoes
- Not the snappiest pick for tempo runs or racers seeking a fast shoe
My Recommendation
I recommend the Brooks Men’s Glycerin GTS 21 for runners who want the softest ride they can wear for everyday training and those who need mild support. If you run a lot of easy miles, recover often, or have a history of shin or knee soreness, the Glycerin GTS 21 offers real relief. It’s not the go-to for speed sessions, but it’s a top choice for comfort-first training.
| Best for | Why |
|---|---|
| Daily long runs | Plush DNA LOFT cushioning absorbs miles comfortably |
| Runners with mild overpronation | GuideRails provide gentle gait control without harsh motion control |
| Recovery and easy days | Soft, forgiving midsole helps speed recovery and reduces impact |
Alternative Products You Can Consider
Brooks Ghost 15 — A neutral daily trainer with balanced cushioning and a lighter feel compared to the Glycerin GTS 21. Best for runners who want cushioning but prefer a bit more responsiveness. It offers a simpler ride without the GuideRails support system, so it’s better if you don’t need stability features.
Hoka Clifton 9 — Known for maximal cushioning and a surprisingly light weight. If you love a soft ride like the Glycerin GTS 21 but want a lighter shoe, the Clifton 9 is a great alternative. It favors smooth transitions and long-run comfort, though it lacks targeted support for overpronation.
ASICS Gel-Nimbus 26 — A plush neutral shoe with gel cushioning and a snug upper. Choose this if you want thick cushioning with a more traditional, stable fit. Compared to the Brooks Men’s Glycerin GTS 21, the Gel-Nimbus leans slightly firmer and offers a different midsole feel.
| Product | Best For | Key Difference |
|---|---|---|
| Brooks Men’s Glycerin GTS 21 | Plush cushioning with mild stability | DNA LOFT cushioning + GuideRails support |
| Brooks Ghost 15 | Neutral runners wanting balanced cushioning | Lighter, more responsive ride without GuideRails |
| Hoka Clifton 9 | Max cushion lovers seeking light weight | Very soft midsole with a lighter overall weight |
| ASICS Gel-Nimbus 26 | Runners wanting plush neutral cushioning | Gel tech feel and a firmer midsole character |
Final Verdict: Which Should You Buy?
If your priority is the softest ride and mild support, buy the Brooks Men’s Glycerin GTS 21. It shines for long easy miles and recovery days. The DNA LOFT foam and GuideRails make it comfortable and confidence-inspiring for many runners.
If you want a lighter, more responsive trainer, consider the Brooks Ghost 15 or the Hoka Clifton 9. If you prefer a firmer plush feel with a traditional fit, the ASICS Gel-Nimbus 26 is a solid alternative. In short: choose the Glycerin GTS 21 for pure comfort and gentle stability.
FAQs Of brooks glycerin gts 21 review
Is the Brooks Men’s Glycerin GTS 21 good for long runs?
Yes. The shoe’s thick DNA LOFT cushioning and supportive GuideRails make it excellent for long, easy runs and recovery days. It absorbs impact well and reduces fatigue over many miles.
Do these run true to size?
Generally yes. The Brooks Men’s Glycerin GTS 21 fits true to size for most runners. If you have wider feet, consider the wide option for extra toe-box space.
Are they suitable for overpronators?
They are suitable for mild to moderate overpronation. The GuideRails system gives lateral support without feeling like a rigid stability shoe. For severe overpronation, a more structured support shoe may be better.
How durable is the cushioning?
The DNA LOFT midsole holds up well for daily training. Expect good cushioning retention across many miles, though all foam will soften over time depending on mileage and care.
Are they good for speed workouts?
Not ideal. The Glycerin GTS 21 favors comfort over responsiveness. For speed sessions, a lighter, firmer trainer or a tempo shoe is a better choice.

Madison Clark is a footwear expert and the voice behind MyStyleGrid.com. She specializes in honest shoe reviews, style tips, and practical guides to help readers find the perfect pair for any occasion. With years of experience in blogging and content creation, Madison makes footwear knowledge simple, stylish, and easy to follow.




